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Specifically, the label states these medications should be used in combination with a reduced calorie diet and increased physical activity. HaVy Ngo-Hamilton, PharmD, pharmacist and clinical consultant for BuzzRx, states that the amount of diet and exercise will vary among users, leading to various degrees of weight loss

Abrupt withdrawal has been linked to severe complications, including Posterior Reversible Encephalopathy Syndrome (PRES), hypertensive encephalopathy, stroke, and death (Thorpe et al., 2025)

It was first identified in human plasma in 1973 by Dr