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By exerting direct effects that modulate key pro-fibrotic pathways and reduce drivers of inflammation, incretin receptor agonists offer a promising approach for treating a broad spectrum of fibrotic and fibro-inflammatory disorders

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This procedure is extremely high-risk, can cause catastrophic joint damage or infection, and should not be attempted in a research context

(C) Relative mRNA expression of inflammatory genes in RAW264.7 macrophages exposed to metabolic stress (0.4 mM palmitate, 10 nM insulin, and 30 mM glucose) with or without Tir for 24 hours