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American journal of physiology

Jzwiak, M., Bauer, M., Kamysz, W., & Kleczkowska, P

5 6 7 With age and chronic stress, GSH can become depleted, leaving organs more vulnerable to oxidative damage, wrinkles, fatigue, brain fog, and inflammation

Using random forest regression as the predictive model, we identified pathways commonly associated with NRF2, such as reactive oxygen species (ROS) and xenobiotic metabolism, in addition to reduced glutathione and NADP levels, as top features associated with NRF2 dependency (Fig