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Moreover, AS-IV has been shown to mitigate obesity-related hypertension by repressing inflammatory responses and enhancing leptin resistance, likely through upregulation of 7nAchR levels and inhibition of IKK/NF-B signaling in the hypothalamus and adipose tissue ( Given the strong link between obesity and arrhythmia, the aforementioned studies suggest that astragaloside may reduce the likelihood of arrhythmia by regulating fat metabolism