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If these measures are insufficient, bulk-forming laxatives such as ispaghula husk or osmotic laxatives like macrogol may be appropriate, following discussion with a GP or pharmacist

The most pronounced differences were observed across gastrointestinal and metabolic events, including nausea (9,651 vs 38,030), vomiting (4,383 vs 17,062), pancreatitis (1,389 vs 6,655), and hypoglycaemia (773 vs 1,778), all substantially lower with combination therapy (Table 1)

The vermilion border, the junction between the white and red part of the lips, is an important area to treat with dermal fillers

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