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The use of vitamin E supplements may increase the risk of bleeding in individuals taking anticoagulant drugs (blood thinners), such as heparin and the vitamin K antagonist, warfarin (Coumadin)
This is a direct, receptor-mediated effect that occurs independently of and in addition to the weight loss driven by reduced caloric intake
It is primarily produced in the central nervous system, and was first isolated from the brains of rabbits that were subjected to sleep by electric stimulation of the intralaminal thalamic area
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