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In humans, EA intervention (180 mg/day, P.O for 8 weeks) significantly fortified the mean of TAC and the activity of GPX enzymes as well as reduced MDA contents in the serum of type 2 diabetic patients [172]

It regulates: Energy homeostasis , complementarily to MC4R but via different pathways Anti-inflammatory effects in macrophages Sebaceous glands (partially) Activation of MC3R contributes to the metabolic and anti-inflammatory effects of Melanotan II, but is less characterized than MC4R