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In parallel, glycine, another major component of collagen, is synthesized from serine, which is derived from the glycolytic intermediate 3-phosphoglycerate via the enzymes phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1), and phosphoserine phosphatase (PSPH), and subsequently converted by serine hydroxymethyltransferase 1/2 (SHMT1/2) [17, 18]

These are generally dose-dependent and resolve with proper dosing adjustment

50 & Target In Vivo max , AUC 0-t , AUC 0- and t 1/2 are 0.34 g/mL, 3.26 g h/mL, 3.67 g h/mL and 2.34 hours, respectively in Sprague-Dawley rats [1]