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Although clinical trials have so far failed to demonstrate relevant clinical benefits of antioxidant (such as vitamin C, vitamin E, and -lipoic acid) to treat T2DM 34 , here we show that TdGSH can fully prevent LOsG/ROS-induced detrimental effects on -cells

Moreover, the conversion of GGC to glutathione only requires 1 molecule of ATP as it is the product of the first step in glutathione synthesis, as shown in Figure 1

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Iqbal et al