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3.2.2 BA and secondary BAs As pivotal messengers bridging the gut microbiota and the host cardiovascular system, the BA familyincluding primary and secondary BAsforms a multifaceted regulatory network through activation of nuclear receptors such as TGR5, FXR, and PXR
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477,478,479 If this is indeed the case, then both types of heart failure are syndromes caused by multiple metabolic and inflammatory changes
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