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The folate-cobalamin interaction is pivotal for normal synthesis of purines and pyrimidines and the transfer of the methyl group to cobalamin is essential for the adequate supply of tetrahydrofolate, the substrate for metabolic steps that require folate

Some protocols combine both, aiming to support both endocrine optimization and local tissue repair

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This combination increases both the amplitude and duration of GH secretion, maximizing downstream IGF-1 production and anabolic effects