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This question arises as obesity rates increase among inflammatory bowel disease patients, prompting interest in GLP-1 receptor agonists like semaglutide (Wegovy) and liraglutide (Saxenda)
Efficacy signal: Trial data shows tirzepatide achieves 20.9% average weight loss (SURMOUNT-1) versus semaglutide's 14.9% (STEP 1), but individual outcomes vary and no obesity-specific switching trial exists yet
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Maridebart cafraglutide (previously known as AMG133) is a bispecific molecule engineered by conjugating a fully human monoclonal anti-human GIPR antagonist antibody to two GLP-1 analogue agonist peptides using amino acid linkers
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