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In hereditary or acquired metabolic defects, an initial intravenous bolus of 50 mg/kg may be administered over two to three minutes, followed by maintenance doses of 50 mg/kg every six hours or continuous infusion to achieve a total daily exposure of up to 300 mg/kg in critical illness
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Serum NO levels tend to increase after LC administration ( P = 0.07) concerning just before administration
New medications under FDA review, such as dual and triple agonists, are showing 20-30% weight loss in trials, monthly dosing options, and more flexible oral formulations are all in late-stage development
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