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Tatem's preference is local injection of BPC-157 with systemic injection of TB-500, based on the reasoning that BPC-157's local effects (angiogenesis at the injury site) benefit from proximity while TB-500's cell migration effects are inherently systemic
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On the other hand, DNA damage-induced ATM activates IGF1/IGF1R in mouse embryonic fibroblasts (Goetz et al., 2011)
The single dose, short (1 h) observation period, and lack of placebo arm are limitations in this proof-of-concept study and provide direction for follow-up studies
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