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lowest tolerated dose Phase Step 2 Weeks Weeks 5-8 Cagrilintide Dose 0.5 mg/week Purpose Dose escalation Phase Step 3 Weeks Weeks 9-12 Cagrilintide Dose 1.0 mg/week Purpose GI side effects often peak here Phase Step 4 Weeks Weeks 13-16 Cagrilintide Dose 1.7 mg/week Purpose Approaching maintenance Phase Maintenance Weeks Weeks 17+ Cagrilintide Dose 2.4 mg/week Purpose Target dose used in late-stage study protocols Each step lasts 4 weeks

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E.2007Human cytosolic sulfotransferase SULT1A1.394(October 2006),685689,1357-2725 49

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The reduced Fe 2 is transported to the cytoplasm by divalent metal transporter 1 (DMT1) and participates in various physiological and biochemical activities, such as DNA biosynthesis, oxygen transport, and metabolic pathway regulation [58]

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