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Included studies were published over the last 22 years: the oldest was published in 2002 (16), the newest in 2021 [19]
EcN 1917 was engineered to target the angiogenesis inhibitor TUM-5 and the tumor suppressor p53 to anaerobic tumor regions, and this treatment significantly inhibited the growth of transplanted tumors in mice 180
doi: 10.1146/annurev.pharmtox.010909.105600 31 RuQLiYChenLWuYMinJWangF
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