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This HO, though less reactive, is still potentially harmful and is further detoxified by CAT and GSH-Px, which break it down into water and oxygen, reducing its potential for cellular damage

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The cleaner independent support is a 2021 study in APP/PS1 Alzheimer's-model mice (Sun 2021, PMID 34827486), which reported improved Morris water maze performance and increased synaptophysin via PI3K/AKT

Given the relatively smaller reduction in body weight (9.4%) in the SELECT trial compared to previous RCTs: 14.9% in STEP1 (BMI 37.86.7 kg/m 2 ) [16] and 13.2% STEP6 (BMI 31.9 kg/m 2 ) [49], pleiotropic effects of semaglutide may contribute to the overall CV risk reduction [25,37]