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Local IGF-1 expression enhances muscle regeneration and reduces inflammation following injury. Musar, A

When produced excessively, it may suppress the release of Thyroid Stimulating Hormone from the pituitary. 18 It also forces T4 to be converted to reverse T3 (rT3) which actually blocks thyroid function, even though thyroxine levels look adequate when tested. 19 Blood glucose imbalance also triggers cortisol secretion, and insulin resistance may have a direct negative effect on the thyroid, too

Experimental systems investigating Epithalon often evaluate oxidative stress markers alongside telomere dynamics