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The regulation of cellular metabolism by reactive oxygen species Reactive oxygen species have pleiotropic effects on cellular processes, including the modulation of cellular signaling and metabolism (Figure 3)

Figure 1 2.1 Overproduction of ROS One hallmark feature of IBD is the overproduction of ROS, which causes dysregulation of signal transduction, an inflammatory response, and DNA damage, all of which contribute to the progression and deterioration of the disease ( 2), nitric oxide (NO), hydroxyl radical (-0H), hydroperoxyl radical (O 2 H), hydrogen peroxide (H 2 O 2 ), and singlet oxygen ( 2.2 Damage to biomolecules ROS can damage various cell biomolecules, including lipids, proteins, and DNA

Tesofensine gained attention in obesity research due to clinical findings showing reduced food intake and meaningful body weight reductions in controlled trials

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