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The binding of insulin with IR causes autophosphorylation of IR [20, 21], activating downstream phosphoinositide-3-kinase (PI3-K)/Akt and mitogen activated protein kinase (MAPK) pathways, which affect the differentiation, energy metabolism and activity of osteocytes [22, 23]

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Yes, under clinical supervision

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The name stands for Mitochondrial Open Reading Frame of the 12S rRNA type-c. It is classified as a mitochondrial-derived peptide (MDP) and is often called an exercise mimetic because it activates the same pathway that hard training does

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