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Brain Res (2019) 1706:11624

These metabolic changes could potentially impact the tumor microenvironment, affecting factors such as nutrient availability and oxidative stress, which are crucial for tumor cell survival and proliferation ( In vitro , SGLT2 exhibited antitumor activity by augmenting caspase 3 cleavage activity and modulating the expression of Bax/Bcl-2 (Figure 3 (Figure 3)

69 In gastric cancer cells, the absence of CDO1 contributed to restore cellular glutathione levels, to prevent ROS and lipid peroxidation, and to promote resistance to ferroptosis, a type of programmed cell death dependent on iron and associated with lipid peroxide accumulation

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