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Apart from the -helical domains of the DNGs that were poorly resolved and masked out, the bound peptide, individual receptor components and heterotrimeric DNGs protein were visible in all maps, allowing robust modelling for all major components of the complexes

And stacking two anti-inflammatory agents in a patient already on biologics or immunomodulators adds complexity that demands prescriber and specialist input

No significant hepatotoxic, nephrotoxic, or immunosuppressive effects have been reported in preclinical literature at research concentrations [5,6]