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Estrogen prevents neuroprotection by caffeine in the mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of parkinsons disease
This effect appeared to be mediated by antioxidant mechanisms involving GSK3 phosphorylation 156 , and it was also associated with a reduction of measures of memory impairment in mice 157
It found that GLP-1 use was associated with a significantly reduced long-term risk of TKA, and effects were greater with longer treatment duration and newer generation GLP-1s