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They can protect lean body mass and micronutrient status during weight loss (which is often rapid with GLP-1s)

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In addition to peripheral effects, certain hepatokines, such as FGF-21, SELENOP, Fetuin-A, ANGPTL3, MANF, Adropin, ApoJ, and SHBG, exhibit direct or indirect effects on the CNS and represent promising therapeutic targets for AD (Figure.2)

4 Treatment groups Active Control Placebo Group Participants will receive once-weekly s.c injections of CagriSema (cagrilintide and semaglutide) at escalating doses every week in 16-week dose escalation period until target dose (dose 2) of CagriSema(cagrilintide and semaglutide) is achieved and maintained up to 24 weeks