Our research group investigated several ligands of BBB nutrient transport systems and the combination of the amino acid alanine and among them the tripeptide glutathione (A-GSH) was the most successful for targeting the BBB in case of nanovesicles [32, 33] or 3-armed poly(l-glutamic acid) (3-PLG) nanocarriers in BBB cultures and animals [24]
By Patricia Van Arnum, Editorial Director, DCAT, [email protected] Whats next Glucagon-like peptide 1 (GLP-1) agonists, used to treat Type 2 diabetes and obesity, have been a success story in the industry, with Novo Nordisk riding a blockbuster wave with Ozempic/Wegovy (semaglutide), respectively for treating Type 2 diabetes and obesity, and Eli Lilly and Company also riding the wave with Mounjaro/Zepbound (tirzepatide), a dual-activating GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 medication, respectively for treating Type 2 diabetes and obesity
instead, they interfere with the chemical process the body uses to create a clot
In the landmark comparative study, GHRP-2 and GHRP-6 increased ACTH and cortisol alongside GH, while Ipamorelin produced a more focused GH response in the tested models