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Variable GPX4 and TfR1 expression levels in papillary thyroid cancer cell lines To examine the relative expression of GPX4 in thyroid cancer cell lines, we performed RT-qPCR on K1, MDA-T32, MDA-T68, and TPC-1 cells, and control human thyroid fibroblasts (HThF)

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We critically evaluate how key host factors, such as gut microbiota composition and glutathione S-transferase (GST) polymorphisms, dictate SFN bioavailability and efficacy, thereby framing a precision nutrition paradigm for its application