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Although several studies have shown positive effects of glutamine supplementation on metabolic variables in diabetes mellitus, there is no systematic review that summarizes the results of these studies
Using advanced tracer methodologies, the researchers identified a fascinating metabolic phenomenon they termed "brain glucose steal." Due to systemic mitochondrial impairment, non-brain organs were essentially stealing glucose intended for the central nervous system, starving the brain of energy and driving cognitive dysfunction
An Y, Xu BT, Wan SR et al (2023) The role of oxidative stress in diabetes mellitus-induced vascular endothelial dysfunction
Notably, the underlying mechanism of SGLT-2 inhibitor-mediated endothelial protection from high glucose is not due to their ability to lower blood glucose but rather to the blockade of the entry of glucose into the endothelium via the endothelial SGLT-2 transporter [130]
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