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The study found that microplastics (MPs) in systemic circulation can be phagocytosed by cells and induce capillary occlusion in the cerebellar cortex, these thromboembolic occlusions reduce blood flow and trigger neurological dysfunction in mice, the mechanism reveals that MPs indirectly impair tissue function by mediating cellular occlusion and disrupting local microcirculation, rather than directly penetrating tissues (66)
26 Adipogenesis is strictly regulated by the transcriptional cascade and signaling pathways (Figure 1)
