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GSTs conjugate 4HNE to GSH, and the corresponding glutathionyl-4-HNE (GS-HNE) is actively transported out of cells via RLIP76, a multifunctional membrane transporter for GSH-conjugated compounds, and/or MRPs (multidrug-resistance proteins

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Do not exceed the stated recommended daily intake

The field has moved from descriptive fuel switching to mechanistic circuits that can be measured and potentially targeted