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Since semaglutide is a pure agonist of the GLP-1 receptor, it exclusively stimulates the phenomena controlled by this receptor, while the ability of tirzepatide to act simultaneously on the GLP-1 and GIP receptors enables the activation of all the processes mediated by these incretins (Figure 3)
Wang WM, Wang X, Duan N, Jiang HL, Huang XF
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On October 5, 2023, an important study, published in JAMA and authored by Mohit Sodhi, indicated an increased risk of gastroparesis, bowel obstruction, and pancreatitis for those using GLP-1 agonists
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