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The compounds could potentially be combined, as their mechanisms do not overlap
How 5-Amino-1MQ Works 5-Amino-1MQ acts by inhibiting nicotinamide N-methyltransferase (NNMT), an enzyme expressed in tissues including adipose, liver, and muscle
While safety monitoring was comprehensive, the trials were not specifically designed to detect rare adverse effects that might occur at rates lower than 1-2%, which would require much larger participant numbers
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