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In this review, we first systematically describe the physiological functions and anabolism of the GSH system, as well as its effects on cardiac injury

Koo GB, Morgan MJ, Lee DG, Kim WJ, Yoon JH, Koo JS, et al

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They represent different generations of incretin agonist development: semaglutide is a mono-agonist (GLP-1R only), tirzepatide a dual agonist (GLP-1R + GIPR), and Retatrutide a triple agonist (GLP-1R + GIPR + GCGR)