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Vitamin B12 supplementation can be an important part of treatment for dogs with any of these conditions: Small intestinal bacterial overgrowth (SIBO) Surgeries that shorten bowel length Cancer of the intestinal tract Familial cobalamin deficiency (a genetic condition) Eating a vegan diet that isnt designed by a veterinary nutritionist Veterinarians will routinely run blood tests to check a dogs vitamin B12 levels after they have diagnosed any of these health problems or if the dog has symptoms that fit with a vitamin B12 deficiency

Biochimica Biophysica Acta, 1741 (1-2), 48-54

Chloramphenicol and other drugs having bone marrow suppressant properties may cause a lack of therapeutic response to vitamin B12