1 Environmental or metabolic stressors, including nutritional state, physical activity, hormonal regulation, and pathological conditions such as heart failure, cancer cachexia, and chronic liver disease, require appropriate fuel selection to maintain metabolic homeostasis
No external incisions are required
Collectively, this indicates a role for CNS GLP-1R populations to mediate food intake suppression by pharmacologic, and to a lesser degree physiologic, GLP-1R agonism
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