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Dehydroascorbate (DHA), an oxidant, is formed from ascorbic acid during the removal of ROS, yet the enzyme responsible for converting DHA back to ascorbic acid is dependent on GSH

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The large number of fragments produced during collision-induced dissociation (CID) further dilute the intensity in MRM mode [7,8]

Consistent with the toxicity of isoniazid in slow acetylators, there is an increased incidence of other drug toxicities in subjects carrying defective alleles, such as lupus erythematosus in patients treated with hydralazine or procainamide (Sim et al., 1988), and haemolytic anemia and inflammatory bowel disease after treatment with sulfasalazine (Chen et al., 2007)