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Therefore, further investigation of the role of neutrophils in disease development, where phagocytosis is affected by soluble uric acid, may be worthwhile in order to clarify whether sUA is indeed a beneficial immunosuppressive agent
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Since DPP4 is found mainly in the meninges and blood vessels, whereas DPP8 and DPP9 are ubiquitously distributed in the brain, it has been hypothesized that NPY is cleaved to the truncated NPY 3-36 in the periphery by soluble DPP4 or membrane-bound DPP4
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