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e , Quantitative mass spectrometry (MS) result showed that depletion of Smurf1 inhibited K48-Nedd8 linkage of PDK1 in Nedd8 R74K HEK293 cells under insulin treatment (n = 5 independent peptides)

Research indicates that HGF activation provides neuroprotective effects in cerebral ischemia, spinal cord injuries, and traumatic brain damage by promoting neuronal survival, stimulating angiogenesis, and reducing apoptosis