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Structure-activity relationship studies have led to the discovery of non-pyridyl class NAMPT activators, which suggest a through-water interaction mechanism within the NAMPT active site 223

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Further research is needed to define subgroups of children with ASD in which these treatments may be most effective as well as confirm their efficacy in DBPC, large-scale multicenter studies

Similar to ErbB2, the RON receptor tyrosine kinase interacts with IGF-IR and confers resistance to IGF-IR inhibitor in childhood sarcoma [178]