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Mol Cell Endocrinol (2009) 297:13740

Second, fatty acid oxidation has been shown to provide NADPH for ROS detoxification [78]

Forecasting Methods Time-series modelling S-curve and diffusion models (for emerging technologies) Driver-based forecasting (GDP, disposable income, adoption rates, regulatory changes) Price elasticity models Market maturity and lifecycle-based projections Scenario Analysis Given inherent uncertainties, three scenarios were constructed: Base-Case Scenario: Expected trajectory under current conditions Optimistic Scenario: High adoption, favourable regulation, strong economic tailwinds Conservative Scenario: Slow adoption, regulatory delays, economic constraints Sensitivity testing was conducted on key variables, including pricing, demand elasticity, and regional adoption

For patients on levothyroxine or other thyroid medications , monitoring should be clinician-guided: Baseline assessment: TSH and free T4 before starting Mounjaro, if not recently checked Consider testing: If clinically meaningful changes occur (significant weight loss, new symptoms, or after substantial dose escalation) Ongoing monitoring: Follow usual annual monitoring when stable, in line with NICE NG145 guidance Post-weight loss: Consider additional testing once target weight is achieved and stabilised Significant weight loss can alter the volume of distribution and metabolism of thyroid hormones, potentially requiring dose adjustments