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doi: 10.1016/j.phrs.2019.104554

These endocrine disturbances result in decreased cortisol synthesis, which in turn may prevent adequate inhibition of T-lymphocyte activation (70, 71)

This well-established importance underlies the role of vitamin B12 deficiency in mood imbalances, psychotic disorders, and neuronal health, particularly in elderly patients, where this deficiency is estimated to affect up to 40% of the population (25, 72)