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(2) Mar M, Morales A, Colell A, Garca-Ruiz C, Fernndez-Checa JC

The metabolic basis of regulated cell death

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There are five different transcription factors under this family that get activated in the presence of pro-inflammatory cytokines, leading to the translocation of P65/P50 dimers stored in the cytoplasm to the nucleus activating cognate B motif, resulting in the expression of the NF-B target gene under the canonical pathway which has been extensively studied than noncanonical pathway activated by tumor necrosis factor (Motolani et al., 2021)