tirzepatide vs retatrutide 10mg is a triple agonist — it targets three receptors at once: GLP-1, GIP, and glucagon. That's what separates it from Ozempic and Mounjaro. Semaglutide (Ozempic/Wegovy) → GLP-1 only. (Mounjaro/Zepbound) → Retatrutide vs Mounjaro: triple agonist

Finally, the cost savings demonstrated by this study may make the use of semaglutide attractive to payers, health maintenance organizations (HMOs), and others with a financial interest in outcomes in patients with T2D, although formal health care cost-effectiveness studies will be needed to balance the costs of the medication with the costs avoided owing to improved ASCVD outcomes

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Sinha F, Federlein A, Biesold A et al (2023) Empagliflozin increases kidney weight due to increased cell size in the proximal tubule S3 segment and the collecting duct