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clinical trials have not identified this as a significant adverse effect

Participants in trials like STEP 1 tend to have extreme obesity (average BMI 38) and receive extensive support (including regular lifestyle counseling (source))

2 Genomics of red hair The redheaded phenotype arises through a mutation in the melanocortin 1 receptor (MC1R) [10,11,12] found on epidermal melanocytes, with loss of receptor function causing disrupted pigment production