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The Mechanism: The "Gatekeepers" of the Liver The study identifies a specific hero in this process: Liver Sinusoidal Endothelial Cells (LSECs)

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Although increased replicative DNA synthesis leading to increased numbers of hepatocytes can explain the liver enlargement induced by 1,2-bis(2-pyridyl)ethylene, an explanation for the liver enlargement induced by tert-butylated hydroxyanisole was not evident