why does tirzepatide work better than semaglutide caused roughly half as many patients to stop treatment because of gastrointestinal side effects as semaglutide. In the first major head-to-head obesity trial, GI side effects caused treatment discontinuation in: Tirzepatide Semaglutide vs Tirzepatide: Key Differences

Scheffer IE, Liao J

Contact your healthcare provider promptly if you experience: Excessive fatigue or weakness Rapid or unexplained weight loss exceeding expected rates Severe, persistent abdominal pain (which may indicate pancreatitis) Persistent vomiting or signs of dehydration New or worsening visual symptoms (particularly if you have diabetic retinopathy) Difficulty maintaining basic daily activities Your healthcare team can assess whether metabolic changes are within expected parameters and adjust your treatment plan accordingly

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Additionally, cost-effectiveness analyses have shown that current GLP-1 pricing does not align with accepted value thresholds, making health systems less likely to support broad reimbursement