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In db/db mouse models of advanced diabetes characterized by uncontrolled hyperglycemia and catabolic weight loss, PG-102 achieved superior and sustained glycemic control compared with semaglutide or tirzepatide while preserving body weight, uncoupling glycemic control from catabolic weight loss

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In studies comparing the effect of oral and parenteral cobalamin, large doses (2 to 3 mg) of daily oral B12 appear equally effective to daily parental cobalamin 1 mg in rapidly restoring cobalamin stores and treating the signs of deficiency (215

The strategy was then applied to semaglutide, a FDA approved GLP-1 analogue, to generate hybrid 24 and we showed that not only the in vivo activity was preserved, but the stability toward pancreatin was improved opening the way for improvement in oral administration