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The mitochondrial protein p32 or gC1qR is overexpressed in tumors with aberrant cell surface expression in tumor cells, tumor lymphatics, and a subset of myeloid cells such tumor-associated macrophages (TAMs) 19
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The pharmacokinetic profiles of these formulations indicate that maximum plasma concentrations are typically attained within 1 to 3 days following SC administration, while steady-state plasma levels are generally achieved after 4 to 5 weeks of once-weekly dosing
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