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Friedman says

73 In summary, peripheral administration of GLP-1RAs either acts directly on the hypothalamus and hindbrain, which lack BBB, or directly crosses the BBB into CNS, which are then projected to other key feeding areas of the brain (Figure 6)

It is a risk

Many cytokines are named according to their functions, such as interleukin (IL), interferon (IFN), colony-stimulating factor (CSF), tumor necrosis factor (TNF), and erythropoietin (EPO)