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Rodents overexpressing USP22 or lncRNA PART1 were well resistant to I/R-induced oxidative stress and cardiac injury, which may be partly attributed to the elevated GSH content in the myocardium [251, 252]

Lauer ME, Majors AK, Comhair S, Ruple LM, Matuska B, Subramanian A, et al

In post-viral syndromes, chronic neuroinflammation often causes excess glutamate to accumulate in the synaptic cleft, where it becomes highly neurotoxic and overstimulates neurons to the point of cell death