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Large cardiovascular outcome trials have demonstrated that several agents in this class reduce major adverse cardiovascular events (MACE) in patients with type 2 diabetes, with benefits extending beyond just those with established cardiovascular disease in some trials

If the initial request is denied, you have the option to appeal the decision, and many patients do succeed in securing coverage through this process." One of the main reasons insurers deny coverage is cost

Malonyl-CoA inhibits the import of fatty acids into the mitochondria, thus reduced levels of malonyl-CoA lead to increased mitochondrial oxidation of long-chain fatty acids as described above